ea0037ep1331 | Clinical Cases–Thyroid/Other | ECE2015
Kermaj Marjeta
, Demaj Enalda
, Sinani Gerta
, Hoxha Violeta
, Husi Gerond
, Cuko Armela
, Ylli Agron
Introduction: Metformin-associated lactic acidosis (MALA) is defined as a high anion gap metabolic acidosis with high circulating lactate levels and without hypoperfusion. It is associated with a mortality rate up to 50%.The reported frequency is 0.01–0.05/1000 patient-years, mostly in patients with predisposing factors (which affect its clearance or energy metabolism) such as altered renal function, congestive heart, hepatic and respiratory failure, concomitant medicatio...